SrasV1, Main, Exploration, bibRecord, 002467

Renin-angiotensin system in human coronavirus pathogenesis.

Identifieur interne : 002467 ( Main/Exploration ); précédent : 002466; suivant : 002468

Renin-angiotensin system in human coronavirus pathogenesis.

Auteurs : Brigitte A. Wevers [Pays-Bas] ; Lia Van Der Hoek [Pays-Bas]

Source :

Future virology [ 1746-0794 ] ; 2010.

RBID : pubmed:32201502

Abstract

Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified species HCoV-NL63 and HCoV-HKU1. HCoVs need host cell proteins to successively establish infections. Proteases of the renin-angiotensin system serve as receptors needed for entry into target cells; this article describes the current knowledge on the involvement of this system in HCoV pathogenesis.

DOI: 10.2217/fvl.10.4
PubMed: 32201502

Affiliations:

Le document en format XML

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<affiliation wicri:level="4"><nlm:affiliation>Center for Experimental & Molecular Medicine, Center for Infection & Immunity Amsterdam, Academic Medical Center, University of Amsterdam, PO Box 226600, 1100 DD Amsterdam, The Netherlands. b.a.wevers@amc.uva.nl.</nlm:affiliation>
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<wicri:regionArea>Center for Experimental & Molecular Medicine, Center for Infection & Immunity Amsterdam, Academic Medical Center, University of Amsterdam, PO Box 226600, 1100 DD Amsterdam</wicri:regionArea>
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<front><div type="abstract" xml:lang="en">Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified species HCoV-NL63 and HCoV-HKU1. HCoVs need host cell proteins to successively establish infections. Proteases of the renin-angiotensin system serve as receptors needed for entry into target cells; this article describes the current knowledge on the involvement of this system in HCoV pathogenesis.</div>
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Renin-angiotensin system in human coronavirus pathogenesis.

Renin-angiotensin system in human coronavirus pathogenesis.

Source :

Abstract

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